Long-term exposure to decabrominated diphenyl ether impairs CD8 T-cell function in adult mice
Identifieur interne : 000082 ( Main/Exploration ); précédent : 000081; suivant : 000083Long-term exposure to decabrominated diphenyl ether impairs CD8 T-cell function in adult mice
Auteurs : Weihong Zeng [République populaire de Chine] ; Ying Wang [République populaire de Chine] ; Zhicui Liu [République populaire de Chine] ; Asma Khanniche [République populaire de Chine] ; Qingliang Hu [République populaire de Chine] ; Yan Feng [République populaire de Chine] ; Weiyi Ye [République populaire de Chine] ; Jianglong Yang [République populaire de Chine] ; Shujun Wang [République populaire de Chine] ; Lin Zhou [République populaire de Chine] ; Hao Shen [République populaire de Chine, États-Unis] ; Yan Wang [République populaire de Chine]Source :
- Cellular and Molecular Immunology [ 1672-7681 ] ; 2014.
Abstract
Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental pollutants that accumulate to high levels in human populations that are subject to occupational or regional industry exposure. PBDEs have been shown to affect human neuronal, endocrine and reproductive systems, but their effect on the immune system is not well understood. In this study, experimental adult mice were intragastrically administered 2,2′,3,3′,4,4′,5,5′,6,6′-decabromodiphenyl ether (BDE-209) at doses of 8, 80 or 800 mg/kg of body weight (bw) at 2-day intervals. Our results showed that continuous exposure to BDE-209 resulted in high levels of BDE-209 in the plasma that approached the levels found in people who work in professions with high risks of PDBE exposure. Reduced leukocytes, decreased cytokine (IFN-γ, IL-2 and TNF-α) production and lower CD8 T-cell proliferation were observed in the mice exposed to BDE-209. Additionally, mice with long-term BDE-209 exposure had lower numbers of antigen-specific CD8 T cells after immunization with recombinant
Url:
DOI: 10.1038/cmi.2014.16
PubMed: 24705197
PubMed Central: 4085518
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental pollutants that accumulate to high levels in human populations that are subject to occupational or regional industry exposure. PBDEs have been shown to affect human neuronal, endocrine and reproductive systems, but their effect on the immune system is not well understood. In this study, experimental adult mice were intragastrically administered 2,2′,3,3′,4,4′,5,5′,6,6′-decabromodiphenyl ether (BDE-209) at doses of 8, 80 or 800 mg/kg of body weight (bw) at 2-day intervals. Our results showed that continuous exposure to BDE-209 resulted in high levels of BDE-209 in the plasma that approached the levels found in people who work in professions with high risks of PDBE exposure. Reduced leukocytes, decreased cytokine (IFN-γ, IL-2 and TNF-α) production and lower CD8 T-cell proliferation were observed in the mice exposed to BDE-209. Additionally, mice with long-term BDE-209 exposure had lower numbers of antigen-specific CD8 T cells after immunization with recombinant <italic>Listeria monocytogenes</italic>
expressing ovalbumin (rLm-OVA) and the OVA-specific CD8 T cells had reduced functionality. Taken together, our study demonstrates that continuous BDE-209 exposure causes adverse effects on the number and functionality of immune cells in adult mice.</p>
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</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
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</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zeng, Weihong" sort="Zeng, Weihong" uniqKey="Zeng W" first="Weihong" last="Zeng">Weihong Zeng</name>
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</tree>
</affiliations>
</record>
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